Klb CLIA Kit for Mouse(Mus musculus) | EIAab.comKlb CLIA Kit for Mouse(Mus musculus)

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Klb (Gene name),

Beta-klotho (Protein name ), KLOTB_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Klb(Betakl);

Protein name:

Beta-klotho(BKL;BetaKlotho);

Alternative:

Klotho beta-like protein;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with FGF19; this interaction is direct. Interacts (via C-terminus) with FGF21; this interaction is direct (By similarity). Interacts with FGFR1 and FGFR4.

Function:

Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21.

Subcellular Location:

Cell membrane Single-pass type III membrane protein

Protein Attributes:

Sequence length:

1043

Sequence:

50:

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1043:

CFISTLAVLL | SITVFHHQKR | RKFQKARNLQ | NIPLKKGHSR | VFS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.45274

KEGG:

mmu:83379

Pfam:

PF00232

String:

Q99N32

SMR:

Q99N32

Uniprot:

Q99N32

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ELISA Kit for Mouse BKL

Cat.:

E1003h

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Packing:

96T

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ELISA Kit for Mouse BKL

Cat.:

E1003m

Price:

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Mouse BKL

Cat.:

U1003h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse BKL

Cat.:

U1003m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse BKL

Cat.:

P1003Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse BKL

Cat.:

P1003Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse BKL

Protein for Mouse BKL

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein."
Ito S. , Kinoshita S. , Shiraishi N. , Nakagawa S. , Sekine S. , Fujimori T. , Nabeshima Y.
Mech. Dev.98:115-119(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
strain: Swiss Webster.
tissue: Liver.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
3.

"Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho."
Ito S. , Fujimori T. , Furuya A. , Satoh J. , Nabeshima Y. , Nabeshima Y.
J. Clin. Invest.115:2202-2208(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
4.

"BetaKlotho is required for metabolic activity of fibroblast growth factor 21."
Ogawa Y. , Kurosu H. , Yamamoto M. , Nandi A. , Rosenblatt K.P. , Goetz R. , Eliseenkova A.V. , Mohammadi M. , Kuro-o M.
Proc. Natl. Acad. Sci. U.S.A.104:7432-7437(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INTERACTION WITH FGFR1 AND FGFR4

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